The Minnesota Vikings remain the NFL's only unbeaten team and will put that record on the line Sunday when they visit the Detroit Lions, who are favored by three points. Other notable Week 8 matchups featuring one-loss teams include the 5-1 Kansas City Chiefs against the Denver Broncos (+1.5) and the Baltimore Ravens facing the 5-1 Buffalo Bills (-3), with quarterback Lamar Jackson returning after a three-game absence due to an ankle injury.
Divisional Matchups Highlight Week 8 Slate
The schedule also features several divisional games: Atlanta Falcons at Tampa Bay Buccaneers (-2.5), Cleveland Browns at Pittsburgh Steelers (-3.5), Indianapolis Colts at Jacksonville Jaguars (-10), New England Patriots at Miami Dolphins (+7), and Philadelphia Eagles at Washington Commanders (-6.5) on Sunday Night Football.
Computer Model Posts Strong Track Record
SportsLine's simulation model, which runs 10,000 simulations per game, has generated more than $5,000 in profit for $100 players on top-rated NFL picks since its inception. Entering Week 8 of the 2026 season, the model holds a 58-51 record on top-rated selections dating back to 2024.
Model Identifies Five High-Confidence Best Bets
The model has locked in five confident NFL best bets for Week 8. A successful parlay of those picks would pay nearly 25-1. Among the highlighted selections is the Over 46.5 points in the Colts-Jaguars game, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, is 6-4 in Indianapolis' last 10 games, and hit in Jacksonville's most recent contest.
Colts-Jaguars Offensive Trends Support Over
Jacksonville ranks seventh in the NFL in scoring, tied with the Chicago Bears at 25.7 points per game. Indianapolis is allowing 25.7 points per game and recently traded away defensive lineman DeForest Buckner. The Colts' offense is led by running back Jonathan Taylor, who has 140 carries for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards with four touchdowns and seven interceptions.
For the Jaguars, quarterback Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, four interceptions, and a 106.3 passer rating in six starts. Wide receiver Parker Washington has emerged as a top target with 26 receptions for 416 yards (16.0 average) and four touchdowns.
Additional Spread Picks Identified
The model also flagged four other Week 8 matchups where it believes the line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations. The full list of best bets and the complete parlay are available through SportsLine.
