College football Week 10 features a loaded schedule with multiple top-25 matchups, and oddsmakers have released opening lines for the weekend's biggest games. The marquee matchup pits No. 1 Miami against No. 5 Notre Dame in South Bend, with the Fighting Irish opening as 4.5-point favorites despite the Hurricanes' top ranking.
Key Matchups
No. 15 LSU hosts No. 10 Alabama in Baton Rouge as a 3.5-point favorite, a game that could serve as a College Football Playoff elimination contest. The Tigers are 1-6 in their last seven home games against the Crimson Tide.
No. 2 Ohio State is a 10.5-point favorite over Oregon after the Buckeyes' loss to USC. Freshman quarterback Luke Fahey is expected to start for Ohio State.
No. 6 Utah is a 4.5-point favorite over No. 8 BYU in the Holy War rivalry, with both teams eyeing a Big 12 championship and playoff berth.
No. 3 Georgia is a 3.5-point road favorite at No. 12 Ole Miss, a potential playoff eliminator for the Rebels.
Other notable lines include No. 11 Texas (-3.5) at No. 23 Missouri, No. 9 Kentucky at No. 16 Tennessee (-6.5), and No. 19 SMU (-6.5) vs. Virginia Tech.
