The Week 10 college football slate features seven matchups involving teams from the initial College Football Playoff rankings, with several one-score lines across major conferences. In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss at +3.5, and Texas faces Missouri at +2.5. The marquee non-conference game sees No. 1 Miami visit No. 11 Notre Dame, with the Fighting Irish favored by 7 points; Miami will be without injured star wide receiver Malachi Toney (ankle). Out west, the BYU-Utah rivalry resumes with Utah favored by 4.5 points at home.
SportsLine's proven computer model, which simulates every FBS game 10,000 times, entered Week 10 with an 80-77 record on top-rated picks this season. The model highlights two key recommendations: Ohio State (-7.5, 45.5) is projected to cover against Oregon in a 3:30 p.m. ET kickoff on CBS and Paramount+, with the Buckeyes covering in over 60% of simulations. Additionally, Oklahoma (+5.5, 45.5) is expected to cover at Florida well over 50% of the time, as the Gators have lost three of four games by 19-plus points and lead the SEC in penalty yards. The model also projects the Over in the Oklahoma-Florida game to hit in 59% of simulations.
The model identifies three upsets in ranked matchups per the poll rankings. Full picks for every FBS game are available via SportsLine. Notable Week 10 games and current odds (subject to change) include: BYU at Utah (-4.5, 49.5), Texas at Missouri (+2.5, 42.5), UCLA at Minnesota (+3.5, 38.5), Alabama at LSU (-6, 52.5), Oregon at Ohio State (-7.5, 45.5), Kentucky at Tennessee (-6, 49.5), Air Force at Army (-4, 43.5), Miami at Notre Dame (-7, 54.5), Michigan State at Michigan (-14, 39.5), Georgia at Ole Miss (+3.5, 56.5), and Oklahoma at Florida (-5.5, 45.5).
