NFL Week 9 score predictions highlight several key matchups with notable trends and expert analysis. The Seattle Seahawks host the Arizona Cardinals on Sunday at 4:25 p.m. ET, with four of their last five meetings in Seattle decided by exactly 10 points. The Seahawks have won 10 straight meetings against the Cardinals regardless of location and enter as 8.5-point favorites, down from an opening line of -12.5. Seattle will be without Leonard Williams, Quenton Nelson, and Rashid Shaheed, while Drew Lock fills in for the injured Sam Darnold.
Other Notable Spreads
Other games with a spread of at least a touchdown include the Detroit Lions vs. Miami Dolphins (+6.5), San Francisco 49ers vs. Las Vegas Raiders (+9.5), and Kansas City Chiefs vs. New York Jets (+9.5).
Expert Analysis
SportsLine expert Eric Cohen, who finished the 2025-26 season with a 188-96-1 straight-up record (66%) and is 70-50-1 (58%) on 2026 picks, has analyzed the full Week 9 slate. Cohen recommends backing the 49ers (-9.5, 51.5) to defeat the Raiders, with the Over also hitting. San Francisco is 8-1 straight-up following their last nine bye weeks, while the Raiders are 1-5 over their last six with a rest disadvantage. Both teams rank in the top six in scoring offense, but Las Vegas ranks 31st in scoring defense compared to San Francisco's sixth-ranked unit.
Key Trends and Injuries
Cohen notes that six straight Raiders games have seen 56 or more points and have hit the Over line. The 49ers will be without receivers Mike Evans (ribs, Achilles), Deebo Samuel (hamstring), and Christian Kirk (knee). Cohen predicts a 34-24 final score in favor of San Francisco and has identified five games projected to be decided by 13 or more points.
