The Buffalo Bills and Minnesota Vikings, both 6-1 and leading their respective divisions, meet on Monday Night Football at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 8:15 p.m. ET. Buffalo enters the game after a 36-10 victory over Baltimore on November 1, while Minnesota suffered its first loss of the season, a 19-15 defeat at Detroit the same day.
The Bills are 3-0 on the road in 2026, and the Vikings are 3-0 at home. Buffalo is a 3.5-point favorite with an over/under of 45.5 points. Key injuries include Vikings quarterback Kyler Murray (hamstring) and receiver Jauan Jennings, both listed as out, while Bills receiver Joshua Palmer (hamstring) is out and headed to injured reserve.
SportsLine's projection model, which simulates each NFL game 10,000 times, favors the Over 45.5 points. The Over has hit in three of Buffalo's last four games and in three of the last four matchups between these teams in Minnesota. The model also indicates one side of the spread hits in more than 50% of simulations. The model entered Week 9 on a 60-51 run on top-rated picks since 2024.
