The Minnesota Vikings aim to rebound from their first loss of the season when they welcome the Buffalo Bills to U.S. Bank Stadium for Monday Night Football. Kickoff is set for 8:15 p.m. ET. Minnesota fell 19-15 at Detroit last week, while Buffalo sits atop the AFC East after a 36-10 victory over the Baltimore Ravens.
The Vikings lead the all-time series 9-6, including a 33-30 overtime win in the most recent meeting in 2022. Minnesota remains undefeated at home this season.
Quarterback Kyler Murray has been ruled out with a hamstring injury, thrusting Carson Wentz into the starting role for the Vikings.
Buffalo enters as a 3.5-point favorite with an over/under of 45.5 points. The money line lists the Bills at -186 and the Vikings at +165.
Expert Analysis
SportsLine's R.J. White, a two-time Westgate Las Vegas SuperContest winner, has posted a 39-17-3 record on his last 59 Vikings picks, returning more than $2,200 per $100 wagered. White is leaning toward the under on the 45.5-point total.
"The Vikings offense is coming off two uninspiring efforts against questionable defenses, and the unit has managed just six offensive touchdowns since Week 2," White said. He notes Minnesota's defense has allowed a league-low 13.3 points per game and the Vikings have gone under the total in nine of their last ten games.
White also identified a key X-factor that makes one side of the spread a strong play, though the specific detail is available through his full analysis.
