NFL Week 10 features several divisional matchups with tight betting trends, and SportsLine expert Eric Cohen has released his exact score predictions for every game. Cohen, who finished the 2025-26 season with a 188-96-1 straight-up record (66%) and is 84-51-1 (62%) on his 2026 picks, including a 14-1 week, highlights key trends for Sunday's slate.
The New York Jets host the Buffalo Bills in a game where recent history suggests a narrow margin. All four Jets home games this season have been decided by three or five points, and two of the last four Bills visits to New York ended with a three-point differential. Buffalo is 10-2 over the last 12 meetings with the Jets, and six of the Bills' last 10 games overall have been decided by three or five points.
Other notable divisional games include the Tennessee Titans hosting the Jacksonville Jaguars (-10.5), Carolina Panthers at New Orleans Saints (-2.5), Minnesota Vikings at Green Bay Packers (-3), and Pittsburgh Steelers at Cincinnati Bengals (-3.5).
Cohen's top pick for Week 10 is the Jaguars (-10.5, 46.5) to win at Tennessee, though he notes the Titans should cover the spread and the under on the total points. The last four Jaguars-Titans matchups averaged just 31.3 combined points, all Jacksonville victories. The Jaguars rank in the top four in both scoring offense and defense and lead the NFL in turnover differential, while the Titans are bottom three in yards gained and allowed and are 1-12 straight-up in their last 13 home games.
"Could Jacksonville be the team to beat in the AFC? They certainly are acting like it, having made significant additions via the trade market on defense this week. In the Jaguars' four-game winning streak over their division rivals, Tennessee has only scored a combined 29 points in those games. Coming off a bye week, expect a slightly better performance from the Titans offense, but I'm not sure the defense will be able to adequately slow Trevor Lawrence and company," Cohen said. He predicts a 27-17 Jaguars victory.
Cohen has also identified five games where the projected point total is at least seven points off the listed over/under, offering potential value on alternate lines. His full Week 10 exact score predictions are available at SportsLine.
