The Buffalo Bills and Minnesota Vikings, both 6-1 and leading their respective divisions, meet on Monday Night Football at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 8:15 p.m. ET.
Buffalo arrives after a 36-10 victory over Baltimore on Nov. 1, while Minnesota suffered its first loss of the season, a 19-15 setback at Detroit the same day. The Bills are 3-0 on the road in 2026; the Vikings are 3-0 at home. Key injuries include Vikings quarterback Kyler Murray (hamstring) and receiver Jauan Jennings, while Bills receiver Joshua Palmer (hamstring) is out and headed to injured reserve.
Current odds list Buffalo as a 3.5-point favorite with an over/under of 45.5 points. The money line sits at Bills -186, Vikings +165.
SportsLine's simulation model, which has generated over $5,000 in profit for $100 players on top-rated NFL picks since inception and entered Week 9 on a 60-51 run dating back to 2024, projects the Over 45.5 points as the slight value side. The Over has hit in three of the last four Bills games and in three of the last four matchups between these teams in Minnesota. With Carson Wentz starting for the Vikings, three Minnesota players are projected to exceed 60 scrimmage yards, while Josh Allen and James Cook are forecast to combine for nearly 125 rushing yards.
The model also indicates one side of the spread hits in more than 50% of simulations; further details are available via SportsLine.
