Week 10 of the college football season features a slate of tight point spreads and high-profile ranked matchups, with several SEC games carrying one-score lines. The SEC highlights include Alabama at LSU (-6.5), Georgia at Ole Miss (+3.5), and Texas at Missouri (+2.5). A top-5 showdown sees No. 1 Miami visiting No. 11 Notre Dame, with the Fighting Irish favored by 7.5 points as Miami will be without injured wide receiver Malachi Toney (ankle). In a rivalry dating back over a century, BYU visits Utah, with the third-ranked Utes favored by 4.5 points at home.
Model Predictions
SportsLine's simulation model, which entered Week 10 with an 80-77 record on top-rated picks this season, projects Ohio State (-7.5) to cover against Oregon in a 3:30 p.m. ET kickoff. The Buckeyes have covered 80% of home games since the start of 2025 and are projected to win by double digits. The model also favors Oklahoma (+6) to cover at Florida, citing quarterback stability for the Sooners with John Mateer averaging 296.5 total yards and four passing touchdowns with zero turnovers over the last two games, while Florida leads the SEC in penalty yards. The model projects the over in that game to hit in 59% of simulations.
Notable Week 10 Games and Spreads
Friday, Nov. 6: Virginia Tech at SMU (-6.5, 56.5); USF at East Carolina (-2.5, 39.5); Nebraska at Illinois (+4.5, 50.5); New Mexico at Nevada (+9.5, 38.5); TCU at Arizona (-7, 46.5). Saturday, Nov. 7: BYU at Utah (-4.5, 48.5); Texas at Missouri (+2.5, 42.5); UCLA at Minnesota (+5, 38.5); Alabama at LSU (-6.5, 52.5); Cincinnati at Houston (-10.5, 62.5); Oregon at Ohio State (-7.5, 45.5); Kentucky at Tennessee (-6.5, 49.5); Air Force at Army (-3, 44.5); Miami at Notre Dame (-7.5, 54.5); Michigan State at Michigan (-14.5, 39.5); Georgia at Ole Miss (+3.5, 56.5); Oklahoma at Florida (-6, 44.5).
