The Week 10 college football schedule features seven matchups involving teams from the initial College Football Playoff rankings, with several games carrying one-score spreads. In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss as a 3.5-point underdog, and Texas faces Missouri as a 2.5-point underdog. Elsewhere, No. 1 Miami visits No. 11 Notre Dame with the Fighting Irish favored by 7 points, while Miami will be without injured wide receiver Malachi Toney. In a rivalry dating back over a century, BYU seeks a fourth straight win over Utah, with the Utes favored by 4.5 points at home.
SportsLine's proven computer model, which simulates every FBS game 10,000 times and entered the week with an 80-77 record on top-rated picks, has released its predictions for every Week 10 matchup. The model recommends Ohio State (-7.5) to cover against Oregon in a 3:30 p.m. ET kickoff on CBS and Paramount+, projecting the Buckeyes to win by double digits and cover more than 60% of the time. Ohio State is coming off a loss at USC, but freshman quarterback Luke Fahey is expected to be more comfortable at home against an Oregon defense that has allowed more passing touchdowns than all but three Big Ten teams.
Another highlighted pick has Oklahoma (+5.5) covering at Florida in over 50% of simulations. The Gators have lost three of their last four games, each by 19 or more points, and lead the SEC in penalty yards. Oklahoma quarterback John Mateer has averaged 296.5 total yards with four passing touchdowns and zero turnovers over his last two games, providing stability. The model also projects the over (45.5) to hit in 59% of simulations for that game.
The model projects three upsets in ranked matchups according to the poll rankings. Full picks for every game are available at SportsLine. Notable Week 10 odds include: BYU at Utah (-4.5, 49.5), Texas at Missouri (+2.5, 42.5), UCLA at Minnesota (+3.5, 38.5), Alabama at LSU (-6, 52.5), Oregon at Ohio State (-7.5, 45.5), Kentucky at Tennessee (-6, 49.5), Air Force at Army (-4, 43.5), Miami at Notre Dame (-7, 54.5), Michigan State at Michigan (-14, 39.5), Georgia at Ole Miss (+3.5, 56.5), and Oklahoma at Florida (-5.5, 45.5).
